Scandinavian Distributor of Medical Diagnostic and Life Science Products

Biogenic Amines & Neuroscience

This product group includes state-of-the-art immunoassays for the analysis of biogenic amines and their derivatives, neurotransmitters, and amino acids.



Catecholamines

2-CAT (Andrenalin/Noradrenalin) RIA & ELISA Fast Track Assays


3-CAT (Andrenalin/Noradrenalin/Dopamine) RIA & ELISA Fast Track Assays


The catecholamines adrenalin, noradrenalin and dopamine are synthesized in the adrenal medulla in the brain. They are involved in a wide range of physiological and pathophsiological conditions. Diseases which are associated with altered levels of catecholamines include hypertonia, degenerative heart diseases, and catecholamine-producing tumors (pheochromocytoma, neuroblastoma, ganglioneuroma). Both single parameter and multiparameter RIA and ELISA kits are available for plasma, urine and other biological fluids including tissue homogenates and micro-dialysates. Key advantages of the assays include:

  • Kits can be used for measuring both plasma and urine with the same standard curve
  • No known drug interferences
  • Elegant and efficient extraction method and reduce incubation times
  • Superior sensitivity/specificity
  • Good correlation with HPLC
  • ELISA kits can be run on open automated ELISA systems

Download information brochures Catecholamine, Dopamine and Catecholamine & Neurotransmittors.



Metanephrines


2-MET Plasma RIA & ELISA Fast Track Assays


2-MET Urine RIA & ELISA Fast Track Assays


Recent studies and publications have shown that the quantification of plasma free metanephrine (fMN) and plasma free normetanephrine (fNMN) is the most accurate biochemical marker for the clinical diagnosis of neuroendocrine tumors, Pheochromocytoma, and follow-up of pheochromocytoma patients. Both RIA and ELISA assays are available for the simultaneous determination of Metanephrine and Normetaneprhine in plasma from just 500 ;Cl. These assays represent a quantum leap in speed and usability. They are faster and more cost effective than any technology including HPLC and LC/MS. Key advantages of the assays include:


  • Speed and ease-of-use
  • No known drug interferences
  • Good correlation with LC/MS
  • Specific for the biologically relevant L-normetanephrine / L-metanephrine
  • Wide standard ranges, convenient measurement of pathological samples without predilution
  • ELISA kits can be run on open automated ELISA systems

Download information brochures Metanephrine and Plasma Metanephrines.


Serotonin and 5-hydroxyindole acetic acid

Serotonin RIA & ELISA Fast Track Assays


5-HIAA (5-Hydroxyindoleacetic acid) ELISA


Serotonin (5-hydroxytryptamine) is an intermediate product of the tryptophan metabolism. It plays an important role as a neurotransmitter in the regulation of different behavioural patterns such as motor activity, aggression, sexuality, appetite, depressions, and sleep. 5-HIAA (5-Hydroxyindoleacetic acid) is the major urinary metabolite of serotonin, an ubiquitous bioactive amine.


Serotonin, and consequently 5-HIAA, are produced in excess by most carcinoid tumors of the intestine and bronchi, especially those producing the carcinoid syndrome. Quantification of urinary 5-HIAA is therefore intended to test for carcinoid.


Other diseases which are associated with altered serotonin concentrations include disorders of the CNS, for example autism, epilepsy, schizophrenia and depression. Low levels of 5-HIAA in the cerebrospinal fluid have been associated with aggressive behavior and suicide by violent means, correlating with diminished serotonin levels. Elevated serotonin levels is one of the most common biological findings in autism and 5-HIAA may be elevated in patients with autistic spectrum disorders. LDN offers RIA and ELISA assays for both clinical routine and research use.


Download information brochures Serotonin and 5HIAA.

Melatonin

Melatonin Direct ELISA & RIA Assays


Melatonin Saliva Direct ELISA & RIA Assays


Melatonin-Sulfate Urine ELISA


Melatonin is an endocrine hormone biosynthesized in the pineal gland from the essential dietary amino acid tryptophan. The serum and saliva melatonin levels in humans show a marked circadian rhythm characterized by very low levels during day time and high levels during night time. Monitoring of serum or plasma levels can aid in the diagnosis of sleep disturbances, such as insomnia. Melatonin is also an early marker for Alzheimer 19s disease.

Key advantages of the assays include:

  • Both ELISA and RIA calibrated to LC-MS/MS
  • Wide standard range, applicable to therapeutic drug monitoring
  • Age and time dependent normal values validated for 6-sulfatoxymelatonin
  • ELISA assay for saliva, urine, serum and plasma

Download information brochures Melatonin Direct and Melatonin Assays.

Other Assays

Please contact us to find out more about assays for histamine, tryptophan, 3-aminobutyric acid (GABA), glutamate,  glycine,  kynurenine, as well as many others, which may be used in clinical routine and research.

Download information brochures Histamine and Research Assays.




Below is a list of our most popular kits within Biogenic Amines & Neuroscience. For a complete list of products, please use product search at the top of the page.


Product Description Product Code
2-CAT ELISA  Fast Track (Adrenaline/Noradrenaline) -(IVD CE) (RUO)
LD-BA E-6500
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3-CAT ELISA  Fast Track (Adrenaline/Noradrenaline/Dopamine) - (IVD  CE)  (RUO)
LD-BA E-6600
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2-CAT RIA Fast Track (Adrenaline/Noradrenaline) - (IVD  CE)  (RUO)
LD-BA R-6500
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3-CAT RIA Fast Track (Adrenaline/Noradrenaline/Dopamine)  - (IVD  CE)  (RUO)
LD-BA R-6600
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2-MET Plasma ELISA Fast Track (Metanephrine/Normetanephrine)
LD-BA E-8300
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2-MET Plasma RIA Fast Track (Metanephrine/Normetanephrine)  - (IVD  CE)  (RUO) LD-BA R-8300
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Serotonin ELISA Fast Track  - (IVD  CE)  (RUO) LD-BA E-8900
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Serotonin RIA Fast Track - (IVD  CE)  (RUO) LD-BA R-8900
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Melatonin Direct RIA  (serum/plasma/saliva) - (IVD  CE)  (RUO) LD-BA R-3300
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5-HIAA ELISA - (IVD  CE)  (RUO) LD-BA E-1900
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GABA ELISA - (IVD  CE)  (RUO)
LD-BA E-2500
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Tryptophan ELISA - (IVD  CE)  (RUO) LD-BA E-2700
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Histamine ELISA - (IVD  CE)  (RUO) LD-BA E-1000
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Histamine Stool ELISA - (IVD  CE)  (RUO) LD-BA E-1200
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Glutamate ELISA - (IVD  CE)  (RUO) LD-BA E-2400
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Kynurenine ELISA LD-BA E-2200
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